CBSE Class 12 Biology Set 1 - (57/2/1) Question Paper 2026 is available for download here. CBSE conducted Class 12 Biology exam on March 27, 2026 from 10:30 AM to 1:30 PM. The Biology theory paper is of 70 marks, and the internal assessment is of 30 marks.
Biology question paper includes MCQs (1 mark each), short-answer type questions (2 & 3 marks each), case-study based questions (4 marks each) and long-answer type questions (5 marks each) which makes up the total of 70 marks.
Download CBSE Class 12 Biology Set 1 - (57/2/1) Question Paper 2026 with detailed solutions from the links provided below.
CBSE Class 12 Biology Question Paper 2026 (Set 1 - 57/2/1) with Solution PDF
| CBSE Official PDF | CD PDF | CD PDF with Solutions |
|---|---|---|
| Download official PDF 1.75 MB | Download Collegedunia PDF 1.07 MB | Download solutions PDF 1.30 MB |
CBSE Class 12 Biology 2026 Set 1 (57/2/1) Questions with Solutions
To separate repetitive DNA from bulk genomic DNA, which of the following method is used ?
In a dihybrid cross, 2400 individuals are produced in \( \mathrm{F_2} \) generation. Approximately how many will be phenotypically similar to parents ?
What could be the reason of extinction of Abingdon Tortoise from Galapagos Islands ?
What conclusion can be drawn if the forelimbs of an aquatic animal and a terrestrial animal have similar anatomical structure ?
How many of the following features are related to Nirodh - a popular brand of condoms ?
(i) Prevention of sexually transmitted infections.
(ii) Phagocytosis of sperms.
(iii) Male contraceptive device.
(iv) Acts as chemical barrier.
(v) Physiological changes in cervical mucus.
A bacterium having radioactive thymidine in its DNA is allowed to multiply in a medium having non-radioactive thymidine for two generations. What percentage of bacteria will have radioactive thymidine in its DNA ?
Which of the following is used to visualize DNA bands under UV light after gel electrophoresis ?
Given below are stages of embryo sac formation from megaspore mother cell. Identify the correct option for the cell division marked a, b, c and d.
[Flow chart: Megaspore Mother cell, arrow a, Megaspore Dyad, arrow b, Megaspore Tetrad, arrow c, Functional Megaspore, arrow d, 7-celled stage of Embryo Sac]
Genetically modified tobacco plants were produced using Agrobacterium vectors. Which property of Agrobacterium helps in carrying nematode specific genes into the host plant ?
Observe the contents 1, 2, 3 and 4 of soil samples I, II and III shown in the graph. If the temperature and moisture of all soil samples are identical, which soil sample(s) will show faster decomposition ?
[Bar graph: Content (%) for soil A (I), soil B (II), soil C (III). 1 indicates lignin content, 2 indicates chitin, 3 indicates nitrogen content and 4 indicates sugar content]
Assertion (A) : Apomixis leads to production of genetically identical off-springs.
Reason (R) : Apomixis involves fertilization between two genetically similar plants.
Assertion (A) : Microbes are used for commercial production of alcohol and beverages.
Reason (R) : Yeast converts glucose into ethanol and carbon dioxide during fermentation.
Assertion (A) : IUCN Red List helps in identifying and protecting endangered species worldwide.
Reason (R) : The list includes the species facing risk of extinction.
Assertion (A) : DNA Ligase is used to join DNA fragments.
Reason (R) : It catalyses the formation of glycosidic bonds between nucleotides.
The diagram below shows the sequence of amino acids in part of haemoglobin molecule.
[Diagram: haemoglobin chain Val, His, Leu, Thr, Pro, Glu, Glu; mRNA line; DNA line with triplets CAT, GTA, AAT, TGA, GGA, CTT (the T marked with *), CTC. Key: Val = valine, His = histidine, Leu = leucine, Thr = threonine, Pro = proline, Glu = glutamic acid]
(i) If the base T (marked with *) is substituted with A, in "CTT" of DNA strand how would it affect the haemoglobin chain ?
(ii) Name the condition and the effects associated with the above substitution.
DNA is considered a more stable genetic material than RNA. Justify this statement with suitable reasons.
After significant reduction of BOD during secondary treatment of sewage, what further processes are carried out ? Mention any one important outcome of these processes.
In some cases, measuring population density by counting individuals may not be feasible. Mention two other parameters that can be used and justify their use with suitable examples.
What factors contribute to the Amazonian rain forests in South America being the most biodiverse regions on Earth ?
(i) Name the organ that forms a connection between foetus and the uterus of a pregnant human female.
(ii) How does it support both nutrition and hormonal regulation ?
Give reasons for :
(i) All copulations do not lead to pregnancy.
(ii) Meiosis I in spermatogenesis and oogenesis are markedly different.
There are limitations of traditional breeding techniques that led to promotion of micro-propagation ?
(a) Mention two advantages of micropropagation.
(b) Give two examples where it is commercially adopted.
(a) Give the scientific name of the organism used by Morgan to study sex-linked traits.
(b) Write any four reasons why this organism made it an ideal experimental model.
Draw a neat diagram of enlarged view of one microsporangium of a Young anther of an angiosperm. Label the different layers of the wall and write the functions of the outermost and innermost layer.
Study the diagram given below :
(a) Name and explain the procedure shown in the diagram. Mention one of its advantage and one disadvantage.
(b) How is "Saheli" different from other oral pills in terms of its composition and advantage ?
S.L. Miller conducted an experiment in 1953 to simulate the conditions of early earth in a laboratory setup.
Answer the following questions based on the experiment :
(a) What was the aim of his experiment ?
(b) Name the gases used and the source of energy.
(a) What is a genetic code ?
(b) Why did scientists feel the need to propose a genetic code ?
(c) Genetic code is said to be "Universal". Why ?
(a) A person inhales dust and pathogens but does not always fall sick. Explain how the body protects against such infections.
(b) Name and describe any two barriers involved in this protection.
Gene manipulation is a fast emerging science. It started with the development of recombinant DNA molecules. This technology which mostly involves cutting and pasting of desired DNA fragments is based on two most important discoveries in bacteria - presence of plasmid and restriction endonucleases. The science of r-DNA technology took birth when Cohen and Boyer (1973) were able to produce a piece of gene containing foreign DNA introduced into plasmid of E.coli.
(a) Name one core technique of biotechnology that alters the genetic material.
Gene manipulation is a fast emerging science. It started with the development of recombinant DNA molecules. This technology which mostly involves cutting and pasting of desired DNA fragments is based on two most important discoveries in bacteria - presence of plasmid and restriction endonucleases. The science of r-DNA technology took birth when Cohen and Boyer (1973) were able to produce a piece of gene containing foreign DNA introduced into plasmid of E.coli.
(b) What is a plasmid ? Mention its importance in biotechnology.
Gene manipulation is a fast emerging science. It started with the development of recombinant DNA molecules. This technology which mostly involves cutting and pasting of desired DNA fragments is based on two most important discoveries in bacteria - presence of plasmid and restriction endonucleases. The science of r-DNA technology took birth when Cohen and Boyer (1973) were able to produce a piece of gene containing foreign DNA introduced into plasmid of E.coli.
(c) Which gene was isolated by Cohen and Boyer and from which bacteria ?
Gene manipulation is a fast emerging science. It started with the development of recombinant DNA molecules. This technology which mostly involves cutting and pasting of desired DNA fragments is based on two most important discoveries in bacteria - presence of plasmid and restriction endonucleases. The science of r-DNA technology took birth when Cohen and Boyer (1973) were able to produce a piece of gene containing foreign DNA introduced into plasmid of E.coli.
(c) How is the action of exonuclease different from that of endonuclease ?
Below is shown a pond that represents a self-sustaining natural ecosystem with both biotic and abiotic components interacting in a balanced food web.
Based on the diagram, answer the questions :
Mention two abiotic components of a pond ecosystem.
Below is shown a pond that represents a self-sustaining natural ecosystem with both biotic and abiotic components interacting in a balanced food web.
Based on the diagram, answer the questions :
Differentiate between the roles of producers and decomposers in such an ecosystem.
Below is shown a pond that represents a self-sustaining natural ecosystem with both biotic and abiotic components interacting in a balanced food web.
Based on the diagram, answer the questions :
Draw a simple food chain operating in such an ecosystem and label each trophic level.
Below is shown a pond that represents a self-sustaining natural ecosystem with both biotic and abiotic components interacting in a balanced food web.
Based on the diagram, answer the questions :
Why is transfer of energy not 100% efficient between trophic levels ?
(i) Explain the role of stigma in pollen pistil interaction.
(ii) Describe the post pollination events leading to double fertilization in angiosperms starting with 2-celled pollen grain.
(i) Explain menstrual phase in the menstrual cycle of human female.
(ii) Why is follicular phase also called proliferative phase ?
(iii) Explain the events that occur in Graafian follicle at the time of ovulation and thereafter.
(iv) Draw a Graafian follicle and label - Antrum and secondary oocyte.
Observe the segment of mRNA given below and answers the questions given below :
(i) Explain and illustrate the steps involved to make fully processed hn RNA.
(ii) Gene encoding RNA polymerase I and RNA polymerase III have been affected by mutation.
Explain its impact on the synthesis of polypeptide giving reasons.
In a particular cattle, the coat colour red and white are controlled by single pair of alleles. A calf that receives allele for red coat from mother and allele for white coat from father shows equal number of red and white hairs on its coat.
(i) Is this an example of Co-dominance or incomplete dominance. Give a reason for your answer.
(ii) With the help of a genetic cross upto \( \mathrm{F_2} \) generation, explain what will be the consequent phenotype of calf when
(1) Red is dominant over white,
(2) Red is incompletely dominant.
A 30 year old man was admitted to a hospital with recurrent infections, weight loss, prolonged fever. His blood report showed a decline in count of T-Lymphocytes thus affecting immune system.
(i) Identify the disease and its causative agent.
(ii) How did the pathogen affect the immune system once it entered the body ? Explain.
(iii) Mention two major modes of its transmission.
(i) Why are microbes considered effective biocontrol agents in sustainable agriculture ?
(ii) Explain the role of the following as biocontrol agents naming the pests or diseases they help to control :
(1) A Bacterium
(2) A Fungus
(3) Virus
CBSE Class 12 Biology Unit-Wise Weightage
| Unit No. | Unit Name | Marks |
|---|---|---|
| VI | Reproduction | 16 |
| VII | Genetics and Evolution | 20 |
| VIII | Biology and Human Welfare | 12 |
| IX | Biotechnology and Its Applications | 12 |
| X | Ecology and Environment | 10 |
| Total | — | 70 |
Comments