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Chromosomes refer to the genetic material that is present in all the cells. They are a thread-like structure. In the nucleus of a eukaryotic cell, each chromosome contains DNA and some proteins which are known as histone proteins. These are responsible for passing on the hereditary traits from one generation to the next. They are given the name chromosomes where chroma means colours and soma means body, as they are stained with specific dyes. Human beings have 23 pairs of chromosomes. This unique structure helps in keeping the DNA tightly packed so that histone proteins could fit inside the cell. Chromosomes are responsible for ensuring that the DNA is equally divided between the daughter cells at the time of the division of the cell. Defective chromosomes can even cause a certain kind of leukaemia in humans. Chromosomal abnormalities or aberrations such as changes in the number or structure of the chromosomes can lead to various genetic disorders such as Turner’s syndrome, Down’s syndrome, etc.
Ques 1. Out of the following living species, which one comprises more than 200 chromosomes?
- Giraffe
- Amoeba
- Chicken
- Buffalo
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Ans. b) Amoeba
Explanation: The giraffe comprises 15 pairs of chromosomes which mean 30 chromosomes. (2n = 30)
Amoeba has a very large genome with over 290 billion base pairs. The Amoeba proteus contains even more than 500 chromosomes in a single nucleus.
Chicken has a diploid number of chromosomes i.e. 78 (2n = 78).
A diploid cell in a buffalo comprises about 60 chromosomes.
Therefore, out of the following, the amoeba is the species having more than 200 chromosomes.
Ques 2. Out of the following options, which one is true related to the composition of chromatin?
- DNA
- RNA
- Proteins
- All of the above
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Ans. d) All of the above
Explanation: Chromatin is a substance in the chromosome that contains DNA, RNA, and proteins. It plays an important role in the structural organisation of chromosomes. It is found inside the nucleus of the eukaryotic cells.
Ques 3. Human beings have how many autosomes?
- 44 pairs
- 23 pairs
- 20 pairs
- 22 pairs
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Ans. d) 22 pairs
Explanation: All the chromosomes apart from the sex chromosomes are known as autosomes. Human beings have 22 pairs of autosomes (44 autosomes). Each person has 46 chromosomes including 44 autosomes and 2 sex chromosomes.
Ques 4. Which of the following causes most of the genetic disorders?
- Mutation
- Gender of a person
- Gross chromosomal abnormalities
- All of the above
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Ans. a) Mutation
Explanation: Most of the genetic disorders are caused due to mutation of a gene. A mutation changes the instructions of a gene to form a protein in a way that the protein is either entirely missing or does not work properly. This can cause a genetic disorder.
Ques 5. What is possessed by each of the chromosomes during the anaphase stage in a bone marrow cell?
- No chromatids
- Two chromatids
- One chromatid
- Three chromatids
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Ans. c) One chromatid
Explanation: Normally a chromosome only has two chromatids. During the anaphase stage, the chromosome splits to form new or daughter chromosomes. There is only one chromatid present in them. Therefore, only one chromatid is present in each of the chromosomes during the anaphase stage.
Ques 6. What are the thread-like structures, that appear within the nucleus during the time of the division of the cell?
- Centrioles
- Centrioles
- Spindle fibres
- Chromosomes
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Ans. d) Chromosomes
Explanation: The chromosomes are thread-like structures that are made up of DNA and proteins. They are present in the DNA. DNA is passed on from the parents to the offspring, it contains the specific instructions that make all the types of living creatures unique.
Ques 7. Who was the first person who observed chromosomes?
- Waldeyer
- Hofmeister
- Strasburger
- Fleming
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Ans. b) Hofmeister
Explanation: Chromosomes were discovered in 1848 by Hofmeister. Strasburger studied chromosomes in 1875 and Waldeyer provided them with their name in 1888. Chromosomes are thread-like structures that are made up of proteins and DNA. They are considered as the carriers of genetic characteristics from the parents to the offspring.
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Ques 8. What do we call a fully expressed allele?
- Dominant
- Homologous
- Heterozygous
- Recessive
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Ans. a) Dominant
Explanation: All of the traits are governed by a pair of alleles that are the alternative forms of a gene. When contrasting alleles are present in the gene of an individual, it is known as heterozygous. As in this genotype, the expression of an allele is masked through the presence of another one, the masked allele is known as recessive while the fully expressed allele is called a dominant allele. They only express the dominant trait irrespective of the presence of both recessive and dominant alleles.
Ques 9. Human beings have how many pairs of sex chromosomes?
- 4 pairs
- 2 pairs
- 3 pairs
- 1 pair
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Ans. d) 1 pair
Explanation: Every human being has 23 pairs of chromosomes in human beings. 1 pair of sex chromosomes are present. These sex chromosomes help in determining the sex of the person. The first 22 pairs of chromosomes are known as autosomes. The remaining 1 pair is of sex chromosomes
Ques 10. Out of the following diseases, which one is known to be sex-linked?
- Alzheimer’s
- Leukemia
- Colour blindness
- Malignancy
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Ans. c) Colour blindness
Explanation: Color blindness is an inherited genetic disorder that is most commonly inherited from the mutations on the X chromosome.
Alzheimer’s is a kind of brain disorder that has multiple problems related to behaviour, memory, and thinking. The condition progresses gradually.
Leukaemia refers to the cancer of the blood-forming tissues of the body, including the lymphatic system and the bone marrow. It is caused by a combination of environmental and genetic factors.
Malignancy is a disease wherein abnormal cells uncontrollably divide and destroy the body tissue.
Ques 11. Which one of the following statements is true with regards to the metaphase?
- During the metaphase, a chromosome is the thickest
- A chromosome is shortest during the metaphase stage
- A chromosome is longest during the metaphase stage
- Both a) and b)
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Ans. d) Both a) and b)
Explanation: Metaphase is a stage of the cell cycle that happens in both mitosis and meiosis cell division processes. During metaphase, the chromosomes condense as they become distinguished and visible and distinguishable during their alignment at the centre of the cell that is dividing, to form a metaphase plate at the centre. During mitotic metaphase, a chromosome is the thickest and shortest.
Ques 12. In males, in which chromosome is the gene for colour blindness located?
- X chromosome
- Y chromosome
- Both X and Y chromosome
- Either X or Y chromosome
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Ans. a) X chromosome
Explanation: Color Blindness is an inherently genetic disorder. Green, red, and blue colour blindness is typically passed on from the parents to the offspring. The gene responsible for this condition is carried by the X chromosome and that is why many more men are affected by this condition as compared to women.
Ques 13. Out of the following, which one plays an important role to link the sister chromatids together immediately after replication:
- Cohesins
- Histones
- Topoisomerases
- Condensins
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Ans. a) Cohesins
Explanation: Cohesins play an important role to link the sister chromatids together immediately after replication as the chromosomes condense to the metaphase stage. They are proteins that belong to the SMC family.
Ques 14. Which out of the following statements is true about the ends of the chromosome?
- The ends of the chromosome are known as Satellites
- The ends of the chromosome are known as Kinetochore
- The ends of the chromosome are known as Centromeres
- The ends of the chromosome are known as Telomeres
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Ans. d) The ends of the chromosome are known as Telomeres
Explanation: The ends of the chromosome are known as a telomere. Telomeres are formed of repeating sequences of the non-coding DNA that helps in protecting the chromosomes from any kind of damage. As the cell division takes place each time, the telomeres continue to become shorter until eventually, they become so short that the cell is unable to divide more.
Ques 15. Which among the following is not a major class of chromatin proteins?
- Histones
- Cohesins
- Topoisomerases
- SMC proteins
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Ans. b) Cohesins
Explanation: Cohesins are not a major class of chromatin proteins. They are proteins in the SMC family. It plays a very important role during mitosis. Cohesins prevent the premature separation of the sister chromatids
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