CUET 2026 May 18 Shift 1 Biology Question Paper is available for download here. NTA is conducting the CUET 2026 exam from 11th May to 31st May.

  • CUET 2026 Biology exam consists of 50 questions for 250 marks to be attempted in 60 minutes.
  • As per the marking scheme, 5 marks are awarded for each correct answer, and 1 mark is deducted for incorrect answer.

Candidates can download CUET 2026 May 18 Shift 1 Biology Question Paper with Answer Key and Solution PDF from links provided below.

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CUET 2026 Biology May 18 Shift 1 Question Paper with Solution PDF

CUET May 18 Shift 1 Biology Question Paper 2026 Download PDF Check Solutions

Question 1:

In the recombinant DNA technology involving plasmid pBR322, insertion of foreign DNA at the PstI restriction site results in the loss of resistance against:

  • (A) Tetracycline
  • (B) Ampicillin
  • (C) Chloramphenicol
  • (D) Kanamycin

Question 2:

Which scientist experimentally demonstrated that DNA replication is semiconservative in nature using \(^ {15}N\) and \(^ {14}N\) isotopes?

  • (A) Watson and Crick
  • (B) Meselson and Stahl
  • (C) Hershey and Chase
  • (D) Griffith

Question 3:

The correct evolutionary sequence in the evolution of modern humans is:

  • (A) Homo habilis \(\rightarrow\) Homo erectus \(\rightarrow\) Neanderthal man \(\rightarrow\) Cro-Magnon man
  • (B) Homo erectus \(\rightarrow\) Homo habilis \(\rightarrow\) Neanderthal man
  • (C) Neanderthal man \(\rightarrow\) Homo habilis \(\rightarrow\) Cro-Magnon man
  • (D) Cro-Magnon man \(\rightarrow\) Homo erectus \(\rightarrow\) Homo habilis

Question 4:

Match the following mammals with their correct category and geographical distribution.

Column-I Column-II
(P) Kangaroo (1) Monotreme found in Australia
(Q) Platypus (2) Marsupial found mainly in Australia
(R) Whale (3) Placental mammal
(S) Echidna (4) Egg laying mammal
 

Choose the correct option.

  • (A) \(P \rightarrow 2,\ Q \rightarrow 1,\ R \rightarrow 3,\ S \rightarrow 4\)
  • (B) \(P \rightarrow 1,\ Q \rightarrow 2,\ R \rightarrow 3,\ S \rightarrow 4\)
  • (C) \(P \rightarrow 2,\ Q \rightarrow 4,\ R \rightarrow 1,\ S \rightarrow 3\)
  • (D) \(P \rightarrow 3,\ Q \rightarrow 1,\ R \rightarrow 2,\ S \rightarrow 4\)

Question 5:

A bioreactor working for industrial production of antibiotics must maintain maximum microbial growth and product formation. Which combination of components is correctly matched with their functions?

Component Function
(P) Sparger (1) Uniform oxygen distribution
(Q) Agitator (2) Uniform mixing of nutrients
(R) Cooling jacket (3) Removal of excess metabolic heat
(S) Foam breaker (4) Prevention of foam accumulation
 

Choose the correct option.

  • (A) \(P \rightarrow 1,\ Q \rightarrow 2,\ R \rightarrow 3,\ S \rightarrow 4\)
  • (B) \(P \rightarrow 2,\ Q \rightarrow 1,\ R \rightarrow 4,\ S \rightarrow 3\)
  • (C) \(P \rightarrow 3,\ Q \rightarrow 2,\ R \rightarrow 1,\ S \rightarrow 4\)
  • (D) \(P \rightarrow 1,\ Q \rightarrow 4,\ R \rightarrow 2,\ S \rightarrow 3\)

Question 6:

Read the following statements carefully regarding scientists and their contributions in genetics.


[(P)] Mendel proposed the law of segregation.
[(Q)] Sutton and Boveri proposed chromosomal theory of inheritance.
[(R)] T.H. Morgan experimentally proved linkage in \textit{Drosophila.
[(S)] Hershey and Chase proved that proteins are genetic material.


Choose the correct option.

  • (A) P, Q and R are correct but S is incorrect
  • (B) P and R are correct but Q and S are incorrect
  • (C) Only P and Q are correct
  • (D) All statements are correct

Question 7:

Which hormone is secreted by the corpus luteum during pregnancy?

  • (A) Estrogen only
  • (B) Progesterone only
  • (C) Progesterone and relaxin
  • (D) Testosterone

Question 8:

Read the following statements regarding Bt cotton and choose the correct option.


[(P)] Bt toxin is produced by \textit{Bacillus thuringiensis.
[(Q)] The inactive protoxin gets activated in the acidic gut of insects.
[(R)] Cry proteins create pores in the epithelial cells of insect midgut.
[(S)] Different cry genes control different groups of insects.

  • (A) P, R and S are correct but Q is incorrect
  • (B) P and Q are correct but R and S are incorrect
  • (C) Only P and R are correct
  • (D) All statements are correct

Question 9:

Match the following mammals in List-I with their correct characteristics in List-II.

List-I List-II
(P) Platypus (1) Marsupial mammal
(Q) Kangaroo (2) Placental mammal
(R) Blue whale (3) Egg laying mammal
(S) Koala (4) Pouch bearing mammal
 

Choose the correct option.

  • (A) \(P \rightarrow 3,\ Q \rightarrow 4,\ R \rightarrow 2,\ S \rightarrow 1\)
  • (B) \(P \rightarrow 1,\ Q \rightarrow 3,\ R \rightarrow 2,\ S \rightarrow 4\)
  • (C) \(P \rightarrow 3,\ Q \rightarrow 1,\ R \rightarrow 4,\ S \rightarrow 2\)
  • (D) \(P \rightarrow 2,\ Q \rightarrow 1,\ R \rightarrow 3,\ S \rightarrow 4\)

Question 10:

During transcription in eukaryotes, the enzyme responsible for synthesis of mRNA is:

  • (A) DNA polymerase
  • (B) RNA polymerase I
  • (C) RNA polymerase II
  • (D) RNA polymerase III

CUET UG 2026 Exam Pattern

Parameter Details
Exam Name Common University Entrance Test (CUET UG) 2026
Conducting Body National Testing Agency (NTA)
Exam Mode Computer-Based Test (CBT)
Exam Duration 60 minutes per test
Total Sections 3 (Languages, Domain Subjects, General Test)
Question Type Multiple Choice Questions (MCQs)
Questions per Test 50 questions (all compulsory)
Marking Scheme +5 for correct, -1 for incorrect
Maximum Marks 250 marks per test
Maximum Subject Choices 5 subjects in total
Syllabus Base Class 12 NCERT (mainly for Domain Subjects)

CUET UG 2026 Question Paper Analysis