Malaria: Causes, Symptoms, Prevention and Life Cycle of Malaria

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Malaria is an infectious disease spread by mosquitoes and caused by various Plasmodium parasitic protozoan microorganisms. Malaria is a disorder that has affected humanity for decades. Mosquitoes preserved in amber nearly 30 million years ago provided the first evidence of this protozoan. The Roman Empire is said to have been brought to its knees as a result of it. Malaria was so widespread during the Roman period that it was also known as "Roman Fever." Today, a French physician named Charles Louis Alphonse Laveran is credited with discovering the parasite. In 1907, he was awarded the Nobel Prize for his discoveries.

Malaria is a potentially fatal disease spread by the bite of an infective female Anopheles mosquito. The plasmodium parasite is carried by infective mosquitos. The parasite is released into the bloodstream when this mosquito bites a person. When within the human body, the parasite travels to the lever, where it matures. The mature parasite enters the body after several days. Infect red blood cells (RBC) in the bloodstream. The parasite within the red blood cells multiplies in 48-72 hours, causing the infected cells to burst open. The parasites begin to infect red blood cells, causing symptoms that come and go in periods of 2-3 days.

Malaria thrives in tropical and subtropical regions, where even the parasites grow. According to the World Health Organization's (WHO) Trusted Source Study, there were an estimated 216 million cases of malaria in 91 countries in 2016.

Key Terms: Malaria, infection, RBCs, parasites, seizures, life cycle of malaria, sporozoite

Causes of Malaria

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Malaria can be caused by a number of causes, including:

  • A malarial vector bit me (Anopheles stephensi)
  • Using tainted and exchanged syringes.
  • Transplantation of organs.
  • Transfusion is a term that refers to the process of
  • During birth, from an infected mother to her child.

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Symptoms of Malaria

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Symptoms of malaria occur 7 to 18 days after infection. Symptoms that are popular include:

  • Fever, nausea, chills, vomiting, and headaches are all symptoms of the flu.
  • Diarrhoea, anaemia, and muscle pain are all symptoms of a weakened immune system.
  • Convulsions and profuse sweating
  • Stools that are bloody.
  • Malaria can be fatal in extreme cases, causing seizures, coma, and ultimately death.

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Stages of Malaria Fever

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Chills, temperature, rigour, and sweating are the symptoms of malaria fever, which are referred to as the cold and sweating phases, respectively.

  • The first cold stage lasts 15-60 minutes and is marked by shivering and a sense of cold.
  • The cold stage is followed by the hot stage, which includes a fever ranging from 39 to 41.5 degrees Celsius that lasts 2 to 6 hours and is accompanied by flushed and dry skin, headaches, nausea, and vomiting.
  • The fever decreases quickly at the end of the cold stage, and the patient sweats profusely for 2-4 hours.

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Mode of Malaria Infection

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Malaria infection takes place in a loop that goes like this:

  • A female anopheles mosquito becomes infected after feeding on a malaria patient.
  • When a mosquito bites a person, it becomes a carrier of the parasite, which then transmits into the human body.
  • The parasite enters the body and then matures in the liver.
  • When the parasites reach maturity, they leave the liver and infect the blood's RBCs.
  • When an uninfected mosquito bites an infected human, the cycle continues.

The following are some other modes of transmission:

  • beginning with the mother and ending with the foetus
  • via a blood transfusion
  • use of mutual needles or syringes

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Life Cycle of Malaria

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The malaria parasite is a sporozoite that passes about. The malarial sporozoites are transmitted through the hosts by the malaria vector, the female Anopheles mosquito. When a person is bitten by an infected mosquito, the sporozoites are injected into the bloodstream from the mosquito's saliva. The sporozoites enter our bodies and build up in the liver. These parasites multiply in the liver by causing damage to the liver and rupturing the body's blood cells. Malaria destroys its victims by killing the red blood cells in their bodies. In the RBCs, the parasites replicate asexually, bursting the cells and releasing more parasites to kill more cells. The malaria parasite releases a toxin called hemozoin when red blood cells are ruptured, inducing the chills in the patient.

The parasites penetrate the female Anopheles mosquito's body along with the human blood it is consuming when it bites an infected human. The parasite's actual growth and maturation takes place within the mosquito's body. The parasites created by humans enter the mosquito's intestine, where male and female cells fertilise each other, resulting in the development of sporozoite. When the sporozoite matures, it breaks free from the mosquito's intestine and migrates to the salivary glands. If they enter salivary glands, they wait until another person is bitten, at which point the infection and disease cycle starts all over again. It is important to note, however, that the malaria parasite develops in two separate hosts: humans and mosquitoes.

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Prevention of Malaria

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Malaria is one of the world's leading causes of preventable death today. It affects over 500 million people worldwide and kills between 1 and 2 million people per year. It is a tropical infectious disease with approximately 90% of cases occurring in Sub-Saharan Africa. Malaria can be treated in two ways - preventing mosquito bites (i.e. preventative measures) or attacking parasites after they have invaded the body.

To avoid mosquitoes from biting, the first approach suggests using mosquito nets and repellents including permethrin. Quinine, a chemical contained in the bark of the cinchona tree, is used in the second type of treatment. Despite the fact that it is not a vaccine, a form of the drug chloroquine has proved to be very effective against malaria.

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Previous Years Questions


Sample Questions

Ques. How can malaria be eradicated? (4 marks)

Ans. Malaria is spread by mosquito bites from infected Anopheles mosquitoes carrying the plasmodium parasite. Female Anopheles mosquitoes, also known as night-biting mosquitoes because they strike most frequently between dusk and dawn, transmit the plasmodium parasite. The spread and breeding of the malaria parasite's host, the anopheles mosquito, must be prevented or managed in human-populated areas in order to prevent the disease from spreading.

  • Remove any standing water in the vicinity of your office or home.
  • Mosquitoes carrying the Anopheles genus are more aggressive at dusk and dawn. As a consequence, try to remain indoors throughout these hours.
  • If you really must go out at dusk or dawn, keep your visibility to a minimum by wearing full-coverage clothing.
  • When going outside, use mosquito repellent creams with a high concentration of N,N-Diethyl-meta-toluamide (DEET).
  • For vector protection, indoor residual spraying (IRS) with insecticides is also recommended.
  • The World Health Organization recommends insecticide-treated mosquito nets for vector control.

Ques. Why can we not make a vaccine of malaria? (3 marks)

Ans. We can, but not in a way that is realistic. For decades, an effective malaria vaccine made of irradiated sporozoites has been available. This vaccine offers relatively good and long-lasting immunity, but there is no realistic way to manufacture large amounts of it, as would be needed for any kind of useful vaccine. Other, more traditional methods have been studied since we know how to produce vast quantities of these vaccines. There has been some improvement, but traditional vaccines are not very successful in general. Malaria is much more complex than the viruses and bacteria that are the most common targets of vaccines; it has a large range of extremely sophisticated ways of blocking and evading host immunity, so it's very capable of handling all but the most broad and efficient immune responses.

Ques. What is malaria vaccine? (4 marks)

Ans. Malaria can be healed in 24 hours and is 100 percent successful. Look up Jim Humble's discovery of the miracle mineral supplement (mms). Jim came across this discovery after contracting malaria while gold prospecting in the jungle. What he found by chance was truly incredible. He discovered that adding lime juice to water purification drops (the kind you buy at the store) improves their effectiveness. The liquid starts a gasification process, which releases oxygen ions into the body, decimating virulent viruses, pathogens, and other bacteria that are causing harm to the body. Since MMS cannot be patented, it has no real profit potential due to its low cost of production and the fact that everyone can produce it in their own kitchen. People also used it to treat malaria, aids, cancer, lymes disease, herpasitic viruses, and other maladies in the body, posing a major challenge to the medical establishment. All of the media outlets ran a huge misinformation campaign at the same time to scare people away from self-healing by telling them that they were drinking bleach, which is easily proved to be a lie by the fact that it isn't bleach. I took that years ago, and it helped a lot of people around me with their wellbeing. In my personal email exchanges with Jim over the years, I considered him to be one of the best humanitarians I've ever met. In other words, you don't need a malaria vaccine because all you need is some water purification drops from your grocery store, fresh squeezed lime juice, and some water to say goodbye to one of the world's leading killers.

Ques. Do animals also suffer from malaria? (3 marks)

Ans. Yes, at least 30 species of simian (monkey) malaria exist. Plasmodium knowlesi is a well-known monkey malaria found in Southeast Asia that is sometimes contracted by humans. In Brazil, P. simium spreads from monkeys to humans. From monkeys to the Yanomamo people of Brazil, P. brasilianum has spread. In mice, P. berghei, P. yoelii, and P. chabaudi cause malaria. Malaria affects birds as well. Plasmodium relictum causes the majority of avian malaria worldwide. Other types of avian malaria, such as those found in ducks, have a negative impact on the poultry industry. Blood parasites of the genus Haemoproteus also cause avian malaria. More than 90 Plasmodium species cause malaria in reptiles, including snakes and, to a lesser degree, lizards. Malaria (Plasmodium bufonis) has been recorded in amphibians such as toads (Bufo), but some authorities are suspicious and are still investigating the reports.

Ques. How do mosquitoes transmit malaria? (3 marks)

Ans. Malaria is spread to humans by female mosquitos of the Anopheles genus. Female mosquitoes need blood meals to carry out egg development, and these blood meals are the parasite life cycle's connection between the human and mosquito hosts. Several factors influence the malaria parasite's ability to evolve in the mosquito. The humidity and temperature with in region, and also some whether or not the Anopheles lives long enough if the parasite to complete its cycle and in mosquito host, are perhaps the most significant considerations. The mosquito host, unlike the human host, does not significantly suffer from the parasite's presence. Except for Antarctica, anophelines can be found all over the world. Depending on the area and climate, various Anopheles species transmit malaria. Malaria-transmitting anophelines can be present not only in malaria-endemic areas, but also in areas where the disease has been eradicated. As a result, the latter areas are still at risk of disease reintroduction.

Ques. How is malaria spread between humans? (4 marks)

Ans. It depends on what you mean by a person's 'having it from.' Human malaria is caused by five different Plasmodium parasite strains. Four of them (Plasmodium falciparum, Plasmodium ovale, Plasmodium vivax, Plasmodium malariae) are only found in humans and have no animal reservoirs. P. knowlesi, which is found mainly in Southeast Asia, infects primates. So, because you are infected with P. knowlesi, the parasite came from another person's infection, and you might claim you "borrowed" it from them in some way. However, the idea of 'having it' from others implies direct dissemination routes such as airborne spread or contamination of bodily fluids. Plasmodium parasites are transmitted indirectly by mosquito vectors, specifically Anopheles species. Only a female Anopheles mosquito bites an infected individual, gets the infection, survives long enough for it to reach her salivary glands (11–17 days), and then bites you. So, in common parlance, most of us will tell you ‘got it' from the mosquito rather than from the human. There have been isolated cases of transmission of infected blood transfusions, which would be the only way to escape the mosquito phase in the transmission cycle, as Shabba de Leon pointed out. However, malaria parasites are not transmitted directly from person to person, and you are not at risk of catching the disease simply by spending time with another person - unless an Anopheles mosquito is involved, which takes a few weeks and isn't guaranteed.

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