This compilation brings together everything CBSE and NEET have asked from Human Health and Disease, the most question-heavy chapter in the Class 12 Biology paper.
- 1-mark questions: 73 questions, mostly MCQ, match-the-disease and assertion-reason from recent papers.
- 2 and 3-mark questions: 67 and 58 questions, the largest combined band in any Biology chapter, built around immunity and pathogens.
- 5-mark long answers: 14 questions, where immunity, AIDS and drug abuse appear most often.
The Human Health and Disease PYQ set gathers 223 board-paper questions across 2003 to 2026, sorted by marks and by year so your practice follows the real exam order.
Every question in this Class 12 Biology Human Health and Disease PYQ compilation is sourced from CBSE board papers (Delhi, Outside Delhi, Foreign and Compartment) and cross-checked against the official mark scheme, with near-duplicate questions removed.
What the Human Health and Disease Previous Year Questions Cover
The 223-question set maps every concept the NCERT chapter introduces. The immune system (innate and acquired, humoral and cell-mediated immunity) drives a large part of every band. Pathogens and the diseases they cause, like malaria, amoebiasis, filariasis, typhoid and the common cold, fill many short questions. AIDS and HIV, cancer, drug and alcohol abuse, and vaccines carry the higher bands, while diagnostic tools like MRI and CT scan appear as MCQs.
Marks-wise Distribution of the Human Health and Disease PYQs
The table below shows how the 223 questions split across the CBSE marks bands. This is the largest PYQ set in the syllabus, so plan your time carefully.
| Marks | Questions | Total Marks | CBSE Section | Type |
|---|---|---|---|---|
| 1 mark | 73 | 73 | Section A | MCQ / Assertion-Reason |
| 2 mark | 67 | 134 | Section B | VSA (Very Short Answer) |
| 3 mark | 58 | 174 | Section C | SA (Short Answer) |
| 4 mark | 11 | 44 | Section D | Case Study |
| 5 mark | 14 | 70 | Section E | Long Answer |
Year-wise Spread of Class 12 Biology Human Health and Disease PYQs
The compilation draws from 22 CBSE board years. Roughly 47% of the questions come from 2023 onwards, with the older years still contributing a strong base of disease and immunity questions.
- 2026: Which option is not a component of the immune system, defining the humoral immune response with two antibody types, and the source plant of opioids with the morphine and heroin link.
- 2024 to 2025: The largest contribution years, with MCQ banks on immunity, AIDS, cancer and diagnostic imaging.
- 2020 to 2023: Reduced-syllabus and pandemic-era papers, yet immunity, pathogens and drug abuse still feature strongly.
- 2003 to 2019: Long answers on the life cycle of malarial parasite, AIDS transmission and the types of immunity, all still in the current syllabus.
Topic Frequency in the Human Health and Disease Board Paper Questions
The 223 questions cluster into the six topic buckets below, ranked by how often CBSE has set them between 2003 and 2026.
| Rank | Topic Cluster | Frequency | Typical Marks Band |
|---|---|---|---|
| 1 | Immune system (innate and acquired immunity, humoral and cell-mediated, antibodies, lymphoid organs) | ~24 per cent | 1, 2, 3, 5 mark |
| 2 | Pathogens and infectious diseases (malaria, amoebiasis, filariasis, typhoid, pneumonia, common cold) | ~22 per cent | 1, 2, 3 mark |
| 3 | AIDS and HIV (transmission, replication in host, prevention, diagnosis) | ~16 per cent | 1, 3, 5 mark |
| 4 | Drug and alcohol abuse (opioids, cannabinoids, source plants, effects, addiction) | ~14 per cent | 1, 2, 3 mark |
| 5 | Cancer and immunology applications (types of tumours, oncogenes, vaccines, organ transplant, allergy) | ~13 per cent | 1, 3, 5 mark |
| 6 | Diagnostic tools and health concepts (MRI, CT scan, immunity and ageing, interferons) | ~11 per cent | 1 and 2 mark |
Marks-Band Attempt Strategy for the Human Health and Disease PYQs
The 223 PYQs are arranged marks-ascending inside the PDF so you can attempt them in the same order the CBSE paper presents them.
- 1-mark questions: Spend no more than 45 seconds each. Many match a disease to its pathogen or test a single immunity fact.
- 2-mark questions: The joint-largest band here, usually a definition plus an example. Keep a pathogen-to-disease table ready for quick recall.
- 3-mark questions: Usually a disease cycle, a type of immunity, or drug effects. Aim for 5 minutes.
- 5-mark long answers: Immunity, AIDS or drug abuse explained in full. Allocate 12 to 15 minutes.
Recent CBSE Trend: 2024 to 2026 Pattern Shift in Human Health and Disease
Three things have changed in the recent CBSE cycles that the Human Health and Disease previous year questions now reflect:
- Section A now carries a fixed block of 1-mark MCQ and assertion-reason questions. The compilation includes 73 such questions, most from 2023 onwards.
- Definition-and-example questions are common, for example the 2026 item asking students to define the humoral immune response and name two antibodies.
- The 2 and 3-mark bands carry the most weight in this chapter, so the PDF gives a deep set of disease, immunity and drug-abuse questions for practice.
Sample Previous Year Questions from Human Health and Disease
Here are a few real previous year questions from the Human Health and Disease board papers, taken straight from the compilation. The full set is in the downloadable PDF.
Which of the following is not a component of immune system?
- Lymphocytes
- Plasma Proteins
- Red Blood Cells
- Bone Marrow
[2026 • 1 mark]
(a) Define Humoral immune response. (b) Name any two types of antibodies found to give humoral immune response in humans.
[2026 • 2 mark]
(a) Mention the scientific name of the source plant and the part from which opioids are extracted. (b) How are morphine and heroin related? Mention the effect each one of them has on human body.
[2026 • 3 mark]
Common Mistakes in the Human Health and Disease Board Questions
- Matching a disease to the wrong pathogen, for example linking amoebiasis to a bacterium instead of Entamoeba.
- Confusing humoral immunity (antibodies, B-cells) with cell-mediated immunity (T-cells).
- Mixing up active and passive immunity, or innate and acquired immunity, in definition answers.
- Describing HIV as a bacterium, or naming the wrong host cell it attacks.
- Listing the wrong source plant for a drug, like attaching opioids to Cannabis instead of the poppy.
Student Feedback on Human Health and Disease PYQ Practice
- 71 per cent said keeping all the pathogens and their diseases apart was the hardest part of this chapter.
- 58 per cent reported gaining 5 to 9 marks after solving the immunity and disease PYQs from this PDF before the boards.
- 50 per cent said an immunity or AIDS question appeared in their actual 2026 paper.
- Average time to finish all 223 PYQs: about 17 hours across 9 study sessions.
How These PYQs Pair with the Other Human Health and Disease Resources
Solving previous year questions alone gives you only half the prep. Pair the PYQ PDF with the matching concept, formula and solution resources for Human Health and Disease.
| Resource | What It Gives You | Open |
|---|---|---|
| NCERT Solutions | Step-by-step worked answers to every NCERT back-exercise question of Human Health and Disease | NCERT Solutions for Human Health and Disease |
| Notes | Concept revision notes covering every topic in the Human Health and Disease chapter | Human Health and Disease Class 12 Notes |
| Formula Sheet | All key formulas and results of Human Health and Disease on one page for last-day revision | Human Health and Disease Formula Sheet |
| Handwritten Notes | Scanned handwritten notes of Human Health and Disease for quick one-shot revision | Human Health and Disease Handwritten Notes |
| Exemplar Solutions | NCERT Exemplar problems of Human Health and Disease solved in full for extra practice | NCERT Exemplar Solutions for Human Health and Disease |
| NCERT Book | Official NCERT Human Health and Disease chapter PDF for free download | Human Health and Disease NCERT Book PDF |
| Exemplar Book | NCERT Exemplar Human Health and Disease problem book PDF for free download | Human Health and Disease Exemplar Book PDF |
How to Use the Human Health and Disease PYQ PDF Most Effectively
The 223 questions are sequenced for a three-pass revision plan:
- Pass 1 (Day 1 to 2): Attempt all 73 one-mark questions. Build a pathogen-to-disease table and re-read the NCERT line behind each wrong answer.
- Pass 2 (Day 3 to 6): Solve the 67 two-mark and 58 three-mark questions, the heart of this chapter, on immunity, diseases and drug abuse.
- Pass 3 (Day 7 to 10): Work through the 14 five-mark long answers, writing immunity, AIDS and drug-abuse answers in full.
All Class 12 Biology Chapter PYQ PDFs
Every Class 12 Biology chapter has its own PYQ compilation built the same way, sorted by marks and tagged by year.
| Chapter | Topic | Previous Year Questions |
|---|---|---|
| Chapter 1 | Sexual Reproduction in Flowering Plants | PYQ PDF |
| Chapter 2 | Human Reproduction | PYQ PDF |
| Chapter 3 | Reproductive Health | PYQ PDF |
| Chapter 4 | Principles of Inheritance and Variation | PYQ PDF |
| Chapter 5 | Molecular Basis of Inheritance | PYQ PDF |
| Chapter 6 | Evolution | PYQ PDF |
| Chapter 7 | Human Health and Disease | PYQ PDF |
| Chapter 8 | Microbes in Human Welfare | PYQ PDF |
| Chapter 9 | Biotechnology: Principles and Processes | PYQ PDF |
| Chapter 10 | Biotechnology and its Applications | PYQ PDF |
| Chapter 11 | Organisms and Populations | PYQ PDF |
| Chapter 12 | Ecosystem | PYQ PDF |
| Chapter 13 | Biodiversity and Conservation | PYQ PDF |
Also Check: NCERT Solutions for Class 12 Biology
Class 12 Biology Human Health and Disease PYQ FAQs
Ques. How many previous year questions are in the Class 12 Biology Human Health and Disease PYQ PDF?
Ans. The PDF has 223 previous year questions from CBSE board papers between 2003 and 2026, the largest PYQ set in the syllabus, sorted by marks (1 to 5) and then by year, latest first. Near-duplicate questions across sets and years are removed.
Ques. Are the Human Health and Disease PYQs based on the 2026-27 CBSE syllabus?
Ans. Yes. Every question follows the 2026-27 CBSE Class 12 Biology syllabus. Older long-form questions are kept because the core ideas, like immunity, pathogens, AIDS and drug abuse, are unchanged in the current syllabus.
Ques. Which topics of Human Health and Disease appear most often in CBSE board papers?
Ans. From the 223-question set: the immune system (about 24 per cent), pathogens and infectious diseases (about 22 per cent), AIDS and HIV (about 16 per cent), drug and alcohol abuse (about 14 per cent), and cancer and immunology applications.
Ques. How is this PYQ PDF different from a CBSE sample paper?
Ans. A sample paper gives you one paper. This PDF stitches together 22 years of questions across every set and region (Delhi, Outside Delhi, Foreign and Compartment) for Human Health and Disease alone, so you can see which diseases and immunity ideas CBSE repeats.
Ques. Does the Human Health and Disease PYQ PDF include MCQs?
Ans. Yes. 73 of the 223 questions are 1-mark questions, mostly MCQ, match-the-disease and assertion-reason from 2023 onwards, when CBSE introduced the Section A objective block.
Ques. Where can I download the Human Health and Disease Class 12 PYQ PDF for free?
Ans. The full Human Health and Disease PYQ PDF is free to download from the PDF button at the top of this page. No sign-up is needed.
Ques. How should I use these PYQs to revise Human Health and Disease in the last 10 days?
Ans. Use the three-pass plan: Day 1 to 2 attempt all 73 one-mark questions, Day 3 to 6 solve the 2 and 3-mark questions (the bulk of this chapter), Day 7 to 10 attempt the 14 long answers. Keep a pathogen-to-disease table ready.
Ques. Is the immune system the most important topic in the CBSE Human Health and Disease questions?
Ans. Yes. The immune system accounts for about a quarter of all the questions in this PDF, across every marks band. Knowing innate vs acquired and humoral vs cell-mediated immunity is the best use of your time for this chapter.
Ques. Does the PDF give answers or only the questions?
Ans. The PDF gives every question with a full step-by-step solution, sorted by marks and year, so you can attempt each one like a practice paper and then check the worked answer.
Ques. What is immunity?
Ans. Immunity is the ability of the body to fight disease-causing pathogens. It is of two main types: innate immunity, which is present from birth and is non-specific, and acquired immunity, which develops after exposure and is pathogen-specific. Acquired immunity is further divided into humoral and cell-mediated immunity.
Ques. How is the humoral immune response defined?
Ans. The humoral immune response is the part of acquired immunity carried out by antibodies in the blood and body fluids. B-lymphocytes produce these antibodies in response to an antigen. The main antibody types are IgG, IgM, IgA, IgE and IgD.
Ques. What is AIDS?
Ans. AIDS (Acquired Immuno Deficiency Syndrome) is a disease caused by the Human Immunodeficiency Virus (HIV). HIV attacks the helper T-cells of the immune system, which weakens the body's defence. It spreads through unsafe sexual contact, infected blood, shared needles and from an infected mother to her child.
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