The GPAT 2025 Exam was conducted on 25th May,2025, shift 2 was held from 2:30 P.M. to 5:30 P.M. in more than 100 exam cities across the country and a CBT Mode with more than 50,000 pharmacy graduates to appear in the exam.
The GPAT 2025 Question Paper was include Pharmaceutical Chemistry, Pharmacology, Pharmaceutics, and Pharmacognosy as the fundamental subjects, containing 125 MCQs, making a total of 500 marks.
GPAT 2025 Shift 2 Question Paper with Answer Key PDF
| GATE 2025 May 25 Shift 2 Question Paper PDF | Download | Check Solutions |
Match the following:
(P) Schedule H
(Q) Schedule G
(R) Schedule P
(S) Schedule F2
Descriptions:
(I) Life period of drugs
(II) Drugs used under RMP
(III) List of Prescription Drugs
(IV) Standards for surgical dressing
Match the following:
(1) Schedule FF
(2) Schedule F3
(3) Schedule V
(4) Schedule Y
Descriptions:
(P) Standards of patent and proprietary medicines
(Q) Requirements and guidelines for clinical trials
(R) Standards for sterilized umbilical tapes
(S) Standards for Ophthalmic preparations
If the label or the container bears the name of an individual or company purporting to be the manufacturer of the drug, which individual or company is fictitious or does not exist, it is:
ISO for quality assurance of Design, Development, Processing, Installation, and Servicing is:
According to the ICH guidelines for stability studies, Climatic Zone II temperature and relative humidity are respectively:
How much volume of Raw spirit can an excise officer withdraw as sample?
Minimum manufacturing space for 'Habb-Unani medicine' as per Schedule of D and C Act?
Manufacturing Specification for tooling has been standardized by?
Match the pair of drugs and their family:
Column A (Drugs):
1. Snake root
2. Artemisia
3. Bitter almond
4. Myrrh
Column B (Family):
(P) Compositae
(Q) Rosaceae
(R) Apocynaceae
(S) Burseraceae
Which of the following alkaloids are found as salts of meconic acid?
Choose the correct statement from the following:
(P) Anthraquinone derivatives are generally detected by Borntrager’s test
(Q) Anthrone is yellow colored and soluble in alkali
(R) Anthranol is insoluble in alkali and shows strong red fluorescence
(S) Borntrager’s test gives negative result with Anthranol (Reduced form)
Choose the correct statement from the following:
(A) Tannin solution precipitate alkaloid
(B) Hydrolysable tannin produce gallic and ellagic acid by enzymatic and acid hydrolysis
(C) Condensed tannin converted into red color substance known as phlobaphene on acid and enzymatic hydrolysis
(D) Tannin are insoluble in water
Trikatu in Ayurveda is a combination of:
Glycogenic amino acids enter TCA cycle except:
Match the following:
(P) Tuberculosis
(Q) Diphtheria
(R) Yellow fever
(S) Malaria
Descriptions:
(1) Bacterial
(2) Viral
(3) Toxoids
(4) Protozoal
Which of the following is used to evaluate disinfectant?
Oral vaccine such as Dukoral® and Shanchol™ is used for prevention of:
Which parasitic worm is responsible for causing lymphatic filariasis?
Which statistical test is used to compare mean of two identical group?
Which enzyme is responsible for albinism?
Which anemia is caused due to Microcytic, hypochromic red blood cells?
Which of the following is the differential test i.e. it does not require the need to make assumption of population following normal or differential distributed?
Which of the following is correct stability order of alkenes?
Cis-trans (E/Z) Isomers, EXCEPT
Number of stereoisomers of 3-bromo-2-butanol:
In Friedel-Crafts reaction, benzene reacts with isopropyl bromide in the presence of aluminium trichloride to give:
Number of conformational isomers of \emph{n}-butane:
Debye is a unit of:
Which is considered an exception to Markovnikov's rule \emph{EXCEPT}:
In Baeyer strain theory, which cycloalkane is more stable?
Walden inversion includes:
Diels-Alder reaction is:
Alkyl halide is converted to alkane:
Aryl diazonium reacts with fluoroborate to give aryl fluoride:
Pyridine is a base with \(K_b\) value:
Naturally occurring pilocarpine is:
In a drug discovery process:
1. Lead optimization
2. Target selection
3. Lead findings
Methotrexate, used as an antimetabolite, is a product of N-methylation of para-aminobenzoic acid and pyridine hydroxyl. The isosteric group is
A/B Trans steroidal hydrogen in the 5th position
Total Number of Carbon atoms in pregnane is
Hypnotics and sedative barbiturate pK\(_a\) value
Structure of hybrid in methadone and meperidine
Steroidal cholestane ring fused with
UV absorbance value of Morphine
Complexometric titration indicators Except
In complexometric titration, the masking agent used to mask Iron (II) ion
Which is used as Fajan's method indicator
Cyanide used in nepheloturbidometry as a salt of
How to prepare 200 mL of a 0.15 M sodium hydroxide solution?
Stationary phase for steroidal chromatography is:
Choose the correct statement in a potentiometric titration: Salt bridge is used as
(i) Prevent contamination of reference electrode to test solution
(ii) No use of design reference electrode of salt bridge
(iii) No effect in test solution
(iv) Solidified with 3% agar
Which of the following is not a Karl Fischer reagent
In Ilkovic equation, m\textprime{} determines
Enzyme activation energy (E\textsubscript{a}) for thermal decomposition of glucose in a first-order reaction is calculated by
In conductometric titration of acetic acid with 0.1 N sodium hydroxide, complete neutralization occurs. Further addition of titrant results in
Vincristine in ultraviolet spectrophotometry \(\lambda_{max}\) value
Which of the following liquids has the highest surface tension at 20°C?
Which diluent is incompatible with primary amines?
Maximum limit of iron used in gelatin for manufacturing Soft Gelatin capsule shell should not exceed
If the log of microorganisms is plotted against time, an initially straight line results. The inverse slope of this line is called
Sedimentation volume is measured by
According to USP, the range of sparingly solubility required to dissolve 1 part of solute should be
Rheogram of which type of flow does not start from the origin
A powder has a Carr's compressibility index in the range of 12-16. The flowability of the powder will be
As per USP, the maximum concentration of benzalkonium chloride used as a preservative in parenteral formulations is
Which of the following is commonly used as a broad-spectrum preservative in pharmaceutical formulations?
Statement of deflocculated suspension
Common name of convective transport
Particle size range of optical microscopy
Select the statement of Smectic liquid crystal
The flow of viscosity increases when the substance is sheared. This is known as
Equipment used in structured breakdown of thixotropy
Thixotropic behavior is associated with
Match the following:
I. True density \hfill (P) Reciprocal of bulk density
II. Granule density \hfill (Q) Graduated cylinder method
III. Bulk density \hfill (R) Helium Pycnometer
IV. Bulkiness \hfill (S) Mercury displacement method
Kozeny-Carman equation is related to
Theory of filtration is related to
The equation \[ \log \left( \frac{P_1}{P_2} \right) = \frac{2.303 \cdot \Delta H_v \cdot (T_2 - T_1)}{R \cdot T_1 \cdot T_2} \]
is related to:
Nitrodisc is an example of which type of Drug Delivery System?
CLASS-II method for tonicity adjustment is:
If the granule density of potassium bicarbonate is 2.350 g/cc and the true density is 3.560 g/cc, determine the interparticle porosity of the powder.
Triple point of water occurs at which temperature and pressure?
In supercritical fluid extraction, what will be the critical temperature (CT) and critical pressure (CP)?
Examples of continuous shelf moving dryer are
An antibiotic dissolves completely in 250 mL of aqueous solution at pH range 1–6.8 and 37°C, and after dissolution, it shows 85% absorption in the body. Based on the Biopharmaceutics Classification System (BCS), in which class does this drug belong?
Manucol is also known as
Which of the following anticancer drugs produces hand-foot syndrome?
Which of the following is a P2Y₁₂ enzyme inhibitor?
Vigabatrin is an inhibitor of
PDE 4 inhibitor used in COPD
Which of the following is an antidote for organophosphorus poisoning?
Which of the following is a Proliferator-Activated Receptor-Alpha (PPAR-α) agonist?
Bambuterol is a prodrug of
Anticonvulsant drug used as a selective molecular target
Common name of convective transport
After which phase of clinical trials do pharmaceutical companies submit a New Drug Application (NDA) to the regulatory authority?
Match the following:
I. Alpha (α) cells \hfill [P] Glucagon
II. Beta (β) cells \hfill [Q] Somatostatin
III. Delta (δ) cells \hfill [R] Gastrin
IV. G cells \hfill [S] Proinsulin
Which of the following drugs, when given with warfarin, induces hepatic CYP450 enzyme?
Blood concentration ratio of the combination of trimethoprim and sulfamethoxazole after being given in a 1:5 ratio is
Furosemide mechanism of action
Match the following drugs and their Mechanism of Action (MOA):
\
Match the following Class and their Antiarrhythmic Drug:
Which effect is associated with amphotericin B?
Which of the following drugs used to treat influenza targets an enzyme?
Choose the correct match of laxative and its Mechanism of Action (MOA):
BPALM combination drug names include moxifloxacin
Mirabegron is used in the management of overactive bladder
Which PDE 4 inhibitor is used in COPD?
5-HT\textsubscript{2A}/2C antagonist used in migraine
If 50% of women who are diagnosed with venous thrombosis are found to be taking oral contraceptives compared to those without thrombosis, which type of study is this?
pH of Jejunum
GnRH agonist EXCEPT
Which of the following are responsible for a rightward shift in the oxygen-hemoglobin dissociation curve?
Match the following Class and their Drug:
(1) Alkylating
(2) Platinum analog
(3) Antimetabolite
(4) EGF receptor inhibitor
(P) 5-fluorouracil
(Q) Cisplatin
(R) Cetuximab
(S) Chlorambucil
Which of the following nasal decongestants is an \(\alpha_2\) agonist?
GPAT 2025 Expected Paper Analysis
As per the previous year's analysis, the GPAT 2025 Question paper is expected to be moderately difficult, with an equal distribution of conceptual, factual and application-based questions in the subject of pharmacy.
| Section/Subject Area | Expected Number of Questions | Expected Difficulty Level | Important Topics |
|---|---|---|---|
| Pharmaceutical Chemistry | 25–30 | Moderate to Difficult |
|
| Pharmaceutics | 20–25 | Moderate |
|
| Pharmacology | 20–25 | Moderate |
|
| Pharmacognosy | 15–20 | Easy to Moderate |
|
| Other Subjects (Biochem, Microbio, etc.) | 15–20 | Moderate | The mix of factual and conceptual questions |
| General Aptitude & Analytical Skills | 10–15 | Easy to Moderate |
|
GPAT 2025 Topic-Wise Weightage
By understanding the topic-wise weightage of GPAT 2025, Candidates can prioritise the high-weightage topics and plan their preparation accordingly. As per the previous year's trends, the question distribution will be as follows:
Pharmaceutical Chemistry
| Topics | Expected No. of Questions |
|---|---|
| Organic Chemistry (Drugs, Reactions) | 8–10 |
| Medicinal Chemistry | 6–8 |
| Analytical Chemistry | 4–6 |
| Physical Chemistry | 2–4 |
Pharmaceutics
| Topics | Expected No. of Questions |
|---|---|
| Dosage Forms & Formulations | 6–8 |
| Biopharmaceutics & Pharmacokinetics | 5–7 |
| Pharmaceutical Engineering & Technology | 3–5 |
| Physical Pharmaceutics | 3–4 |
3. Pharmacology
| Topics | Expected No. of Questions |
|---|---|
| General Pharmacology | 5–6 |
| Autonomic Nervous System | 4–6 |
| Cardiovascular, CNS & Chemotherapy Drugs | 5–7 |
| Adverse Effects & Drug Interactions | 2–4 |
4. Pharmacognosy
| Topics | Expected No. of Questions |
|---|---|
| Plant Constituents & Sources | 5–6 |
| Phytochemistry | 4–5 |
| Herbal Formulations & Applications | 2–4 |
Other Subjects
| Topics | Expected No. of Questions |
| Microbiology & Biotechnology | 3–4 |
| Biochemistry | 2–3 |
| Clinical Pharmacy & Health Education | 2–3 |
| Pharmaceutical Jurisprudence & Ethics | 2–3 |
| General Aptitude (Quant + Logical) | 10–15 |
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