NIPER JEE Question Paper 2025 (Available): Download Solution Pdf with Answer Key

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Shivam Yadav

Updated 3+ months ago

The NIPER JEE 2025 exam for admission to M.S. (Pharm), M.Pharm, M.Tech (Pharm), and Ph.D. programs is being held on June 10th, 2025,  in CBT Mode across designated centers in India.

The NIPER JEE 2025 Question Paper with answer key and solution PDF will be available for download. The exam comprises 200 multiple-choice questions divided into two key sections: Subject-Specific (Pharmaceutical Sciences) and General Aptitude.

NIPER JEE 2025 Question Paper with Answer Key (Memory Based)

NIPER JEE 2025 Question Paper with Answer Key Download PDF Check Solutions
NIPER JEE Question Paper

Question 1:

Which of the following antipsychotic drugs works by blocking post-synaptic dopamine D2 receptors, particularly in the mesolimbic-mesocortical pathway?

  • (a) Haloperidol
  • (b) Clozapine
  • (c) Olanzapine
  • (d) Risperidone

Question 2:

Neutropenia is an adverse effect of all of the following drugs EXCEPT:

  • (a) Clozapine
  • (b) Carbamazepine
  • (c) Phenytoin
  • (d) Lithium

Question 3:

The mode of action of nerve gas is:

  • (a) Inhibition of acetylcholinesterase
  • (b) Blockade of sodium channels
  • (c) Inhibition of gamma-aminobutyric acid (GABA)
  • (d) Activation of muscarinic receptors

Question 4:

Friedel-Crafts reaction is observed in:

  • (a) Aromatic compounds
  • (b) Aliphatic compounds
  • (c) Alcohols
  • (d) Aldehydes

Question 5:

Which of the following peptides is cyclic in nature?

  • (a) Oxytocin
  • (b) Insulin
  • (c) Glucagon
  • (d) Vasopressin

Question 6:

The time taken for 5 percent of a drug to decompose by first-order kinetics is:

  • (a) Half-life
  • (b) Mean residence time
  • (c) Shelf-life
  • (d) None of the above

Question 7:

Which are the host cell membrane receptors that the outer coat protein gp-120 of HIV binds to?

  • (a) CD4 and CCR5
  • (b) CD8 and CXCR4
  • (c) CD4 and CXCR4
  • (d) CD8 and CCR5

Question 8:

A partial theoretical support for the idea that more stable carbocations would be formed faster than less stable ones comes during regioselective addition of HCl to propene, provided by:

  • (a) Markovnikov's Rule
  • (b) Le Chatelier's Principle
  • (c) Hess's Law
  • (d) None of the above

Question 9:

Which form of electrochemical measurement does NOT involve electrolysis?

  • (a) Potentiometry
  • (b) Voltammetry
  • (c) Coulometry
  • (d) Amperometry

Question 10:

In LC-MS (Liquid Chromatography-Mass Spectrometry) instrument, the interface is applied between:

  • (a) Liquid chromatography and UV detector
  • (b) Liquid chromatography and mass spectrometer
  • (c) UV detector and mass spectrometer
  • (d) None of the above

NIPER JEE 2025 Marking Scheme

The NIPER JEE tests candidates’ subject knowledge in pharmaceutical sciences and general aptitude. The paper comprises 200 multiple-choice questions, with each correct answer awarded 1 mark. There is a penalty of 0.25 mark for every incorrect answer.

Section Number of Questions Marks Allotted Marking Scheme
Subject-Specific Questions (Pharmaceutical Sciences) 160 160 +1 for correct answer
-0.25 for wrong answer
General Aptitude 40 40
Total 200 200 Negative marking applies

NIPER JEE Questions

  • 1.
    A partial theoretical support for the idea that more stable carbocations would be formed faster than less stable ones comes during regioselective addition of HCl to propene, provided by:

      • Markovnikov's Rule
      • Le Chatelier's Principle
      • Hess's Law
      • None of the above

    • 2.
      The time taken for 5 percent of a drug to decompose by first-order kinetics is:

        • Half-life
        • Mean residence time
        • Shelf-life
        • None of the above

      • 3.
        Friedel-Crafts reaction is observed in:

          • Aromatic compounds
          • Aliphatic compounds
          • Alcohols
          • Aldehydes

        • 4.
          Which of the following drug transport mechanisms across the cell membrane is bidirectional in nature?

            • \( \text{Passive diffusion} \)
            • \( \text{Active transport} \)
            • \( \text{Pinocytosis} \)
            • \( \text{Facilitated diffusion} \)

          • 5.
            Captisol is an excipient based on:

              • \( \text{PLA polymer} \)
              • \( \text{PLGA polymer} \)
              • \( \text{Cyclodextrin} \)
              • \( \text{PEG} \)

            • 6.
              This reaction mechanism is favored by \( 3^{\circ} \) substrates, low temperatures, polar solvents, and low concentrations of very weak bases.

                • \( \text{E1} \)
                • \( \text{E2} \)
                • \( \text{SN1} \)
                • \( \text{SN2} \)

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